PReS-FINAL-2050: Determination of the concentration of methotrexate in the blood serum of patients with JIA

Introduction Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease among children. Among patients with JIA often meets resistance to the therapy of various drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), intraarticular injections and physiotherapy. For the treatment of JIA is used several groups of drugs: NSAIDs, corticosteroids (CS), immunosuppressive drugs and biologically active substances obtained genno-ingenerian. Application NSAIDs and GS have anaesthetic and anti-inflammatory effects, but do not contribute to the prevention of destruction of the joints and disability of patients. The ≪gold standard≫ in the treatment of JIA can be considered methotrexate (MTX) cytostatic drug groups of antimetabolites, antagonists folic acid. MTX has expressed immunosupression action, even at relatively low doses, with no noticeable hematologic toxicity. Despite this, when taking methotrexate recommended clinical and laboratory monitoring is needed to prevent side effects. According to various authors, about 70% of patients receiving MTX consists in the remission of the disease.